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The mechanism is unknown and pharmacokinetic studies with hydrochlorothiazide have not demonstrated any effects on the disposition of allopurinol or oxipurinol (its major metabolite). Allopurinol will not relieve a gout attack that has already started. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients. The following information includes only the average doses of allopurinol. After you have been taking allopurinol regularly for several months, the attacks may stop completely. MetabolicKrasinger and colleagues suggest that it may be reasonable to add allopurinol to the pancreatic enzyme treatment regimen in CF patients that have a urine pH of less than 6 and also excrete large amounts of uric acid.
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